Molecular chaperones and their denaturing effect on client proteins
نویسندگان
چکیده
منابع مشابه
Molecular chaperones, stress proteins and redox homeostasis.
Protection against oxidative stress is highly interrelated with the function of the most ancient cellular defense system, the network of molecular chaperones, heat shock, or stress-proteins. These ubiquitous, conserved proteins help other proteins and macromolecules to fold or re-fold and reach their final, native conformation. Redox regulation of protein folding becomes especially important du...
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In response to stress stimuli, mammalian cells activate an ancient signaling pathway leading to the transient expression of heat shock proteins (HSPs). HSPs are a family of proteins serving as molecular chaperones that prevent the formation of nonspecific protein aggregates and assist proteins in the acquisition of their native structures. Physiologically, HSPs play a protective role in the hom...
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ژورنال
عنوان ژورنال: Journal of Biomolecular NMR
سال: 2020
ISSN: 0925-2738,1573-5001
DOI: 10.1007/s10858-020-00353-7